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Case 281 - Discussion

Hematopathology Case


  • Diagnosis:

    • Acute myeloid leukemia with inv(3)(q21q26.2)

    • 50% blasts involving a normocellular marrow (40%)

  • Flow cytometry:

    • Positive for a distinct blastic population, with expression of dim CD45, CD7, dim CD13, dim CD33, CD34, CD38, CD117, HLA-DR, and dim MPO

  • Cytogenetics studies:

    • 45,XX,inv(3)(q21q26.2),-7

  • FISH studies:

    • Positive for EVI1 rearrangement and loss of 7q31


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