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Case 238 - Discussion

Hematopathology Case


Acute Myeloid Leukemia With Inv16 or t(16;16)

  • Breakpoint junction: core binding factor (CBFB) at 16q22 and smooth muscle myosin heavy chain (MYH11) at 16q13

  • Blasts have myelomonocytic features

  • Blasts positive for CD34, CD117, granulocytic markers (CD13, CD33, CD15 and MPO), and monocytic markers (CD4, CD11b, CD11c, CD14, CD64, CD36 and lysozyme)

  • Aberrant CD2 expression in a subset of cases

  • Abnormal eosinophils with large, basophilic granules (so called "pizza" cells)

  • Favorable prognosis in the absence of KIT mutations.